8.14 % | The Vanguard Group, Inc. | 22,764,739 | 669,350 | 31.12.2023 |
7.15 % | MHR Fund Management LLC | 19,997,103 | 0 | 31.12.2023 |
6.87 % | Perceptive Advisors LLC | 19,221,743 | 7,242,328 | 20.2.2024 |
6.04 % | BlackRock Institutional Trust Company, N.A. | 16,898,233 | 680,727 | 31.12.2023 |
5.87 % | State Street Global Advisors (US) | 16,424,388 | -307,881 | 31.12.2023 |
2.39 % | Avoro Capital Advisors LLC | 6,700,000 | 0 | 31.12.2023 |
10.03 % | Quogue Capital L.L.C. | 28,067,333 | 5,000,000 | 20.2.2024 |
1.88 % | Pictet Asset Management Ltd. | 5,263,309 | -1,650,375 | 31.12.2023 |
1.80 % | Geode Capital Management, L.L.C. | 5,037,098 | 287,687 | 31.12.2023 |
1.73 % | Artisan Partners Limited Partnership | 4,827,670 | -208,809 | 31.12.2023 |
1.68 % | OrbiMed Advisors, LLC | 4,707,458 | 0 | 31.12.2023 |
1.40 % | Balyasny Asset Management LP | 3,926,159 | -550,677 | 31.12.2023 |
1.26 % | Dimensional Fund Advisors, L.P. | 3,516,987 | -461,398 | 31.12.2023 |
1.18 % | BioImpact Capital LLC | 3,289,470 | 2,073 | 31.12.2023 |
1.13 % | T. Rowe Price Associates, Inc. | 3,153,086 | -318,633 | 31.12.2023 |
1.05 % | Morgan Stanley & Co. LLC | 2,926,065 | 929,531 | 31.12.2023 |
1.00 % | Goldman Sachs & Company, Inc. | 2,811,932 | -161,559 | 31.12.2023 |
0.94 % | Principal Global Investors (Equity) | 2,636,327 | -6,828 | 31.12.2023 |
0.91 % | Credit Suisse Funds AG | 2,557,380 | -2,533 | 31.12.2023 |
0.76 % | Long Focus Capital Management LLC | 2,135,521 | -335,000 | 31.12.2023 |
0.75 % | Palo Alto Investors LP | 2,106,792 | 2,106,792 | 31.12.2023 |
0.72 % | Hood River Capital Management LLC | 2,001,510 | 9,175 | 31.12.2023 |
0.70 % | Northern Trust Investments, Inc. | 1,954,979 | 183,827 | 31.12.2023 |
0.63 % | Rice Hall James & Associates, LLC | 1,750,907 | 28,196 | 31.12.2023 |
0.63 % | 683 Capital Management LLC | 1,750,000 | -300,000 | 31.12.2023 |
0.62 % | Charles Schwab Investment Management, Inc. | 1,747,023 | 54,490 | 31.12.2023 |
0.62 % | Candriam Belgium S.A. | 1,727,822 | -1,020,031 | 31.12.2023 |
0.60 % | Candriam Luxembourg S.A. | 1,692,770 | 0 | 29.2.2024 |
0.57 % | Woodline Partners LP | 1,604,706 | 958,411 | 31.12.2023 |
0.57 % | JPMorgan Asset Management U.K. Limited | 1,602,777 | -44,401 | 31.12.2023 |
0.57 % | Susquehanna International Group, LLP | 1,598,930 | 353,893 | 31.12.2023 |
0.54 % | DWS Investments UK Limited | 1,524,812 | 1,412,125 | 31.12.2023 |
0.50 % | Boxer Capital, L.L.C. | 1,400,000 | -2,305,133 | 31.12.2023 |
0.49 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1,360,000 | 0 | 31.12.2023 |
0.45 % | Rafferty Asset Management LLC | 1,247,515 | -248,655 | 31.12.2023 |
0.40 % | Norges Bank Investment Management (NBIM) | 1,120,457 | -1,854,400 | 31.12.2023 |
0.40 % | Rhenman & Partners Asset Management AB | 1,116,818 | 166,818 | 31.12.2023 |
0.38 % | Invenomic Capital Management LP | 1,053,251 | -42,946 | 31.12.2023 |
0.37 % | New York State Common Retirement Fund | 1,021,824 | -5,141 | 31.12.2023 |
0.37 % | Schonfeld Strategic Advisors LLC | 1,021,818 | 1,021,818 | 31.12.2023 |
0.36 % | Tang Capital Management, LLC | 1,000,000 | 1,000,000 | 31.12.2023 |
0.35 % | Voloridge Investment Management, LLC | 983,080 | 782,656 | 31.12.2023 |
0.34 % | Millennium Management LLC | 939,546 | -6,880,528 | 31.12.2023 |
0.33 % | BofA Global Research (US) | 936,887 | -293,181 | 31.12.2023 |
0.33 % | Nuveen LLC | 930,818 | -638,955 | 31.12.2023 |
0.33 % | JP Morgan Asset Management | 926,109 | -63,353 | 31.12.2023 |
0.32 % | Opaleye Management Inc. | 897,000 | 287,000 | 31.12.2023 |
0.31 % | BlackRock Financial Management, Inc. | 859,954 | -119,170 | 31.12.2023 |
0.31 % | T. Rowe Price Investment Management, Inc. | 858,100 | 858,100 | 31.3.2024 |
0.31 % | UBS Financial Services, Inc. | 857,308 | 618,755 | 31.12.2023 |
0.30 % | Goldman Sachs Asset Management, L.P. | 845,818 | 66,388 | 31.12.2023 |
0.30 % | Barclays Bank PLC | 836,175 | 78,243 | 31.12.2023 |
0.28 % | Banque Pictet & Cie S.A. | 778,038 | 144,244 | 31.12.2023 |
0.27 % | Pictet Asset Management (Japan) Ltd. | 746,057 | 279,233 | 31.10.2023 |
0.26 % | Citi Investment Research (US) | 721,210 | -182,340 | 31.12.2023 |
0.25 % | Brevan Howard Capital Management LP | 692,775 | -869,911 | 31.12.2023 |
0.24 % | QVT Financial LP | 678,564 | 0 | 31.12.2023 |
0.24 % | Cutter Capital Management, LP | 677,350 | 677,350 | 31.12.2023 |
0.23 % | Vivo Capital, LLC | 655,057 | 0 | 31.12.2023 |
0.23 % | Invesco Capital Management LLC | 652,170 | 570,056 | 31.12.2023 |
0.23 % | Laurion Capital Management LP | 637,742 | 637,742 | 31.12.2023 |
0.22 % | BlackRock Investment Management, LLC | 615,971 | 22,555 | 31.12.2023 |
0.22 % | BNY Mellon Asset Management | 602,181 | 4,931 | 31.12.2023 |
0.21 % | Parametric Portfolio Associates LLC | 578,893 | 268,044 | 31.12.2023 |
0.21 % | Group One Trading, L.P. | 576,302 | -49,399 | 31.12.2023 |
0.20 % | Farallon Capital Management, L.L.C. | 562,000 | 562,000 | 31.12.2023 |
0.20 % | McPeak (Merrill A) | 558,783 | 250,000 | 20.2.2024 |
0.20 % | Soleus Capital Management, L.P. | 555,000 | -684,777 | 31.12.2023 |
0.20 % | BNP Paribas Securities Corp. North America | 552,847 | 251,536 | 31.12.2023 |
0.19 % | Jane Street Capital, L.L.C. | 522,561 | -27,354 | 31.12.2023 |
0.18 % | Zimmer Partners, LP | 495,000 | -93,000 | 31.12.2023 |
0.17 % | Cubist Systematic Strategies, LLC | 468,821 | 468,821 | 31.12.2023 |
0.16 % | Eagle Asset Management, Inc. | 450,456 | 450,456 | 31.12.2023 |
0.16 % | International Biotechnology Trust PLC | 445,000 | 380,000 | 30.9.2023 |
0.16 % | Schweizerische Nationalbank | 439,456 | -49,900 | 31.12.2023 |
0.15 % | Hennion & Walsh Asset Management, Inc. | 407,429 | 121,395 | 31.3.2024 |
0.14 % | Medical Strategy GmbH | 393,779 | 0 | 30.9.2023 |
0.14 % | DWS Investment GmbH | 390,600 | 0 | 31.12.2023 |
0.14 % | Arctic Fund Management AS | 385,029 | -12,100 | 29.2.2024 |
0.13 % | Simplex Trading, LLC | 374,067 | 198,650 | 31.12.2023 |
0.13 % | Rhumbline Advisers Ltd. Partnership | 368,456 | 16,289 | 31.12.2023 |
0.13 % | Corient Private Wealth LLC | 367,000 | 247,199 | 31.12.2023 |
0.12 % | PanAgora Asset Management Inc. | 346,190 | 12,216 | 31.12.2023 |
0.12 % | American Century Investment Management, Inc. | 333,136 | -75,622 | 31.12.2023 |
0.12 % | Lombard Odier Asset Management (Europe) Ltd | 331,776 | -71,654 | 30.9.2022 |
0.12 % | Schroder Investment Management Ltd. (SIM) | 324,736 | 324,736 | 31.12.2023 |
0.11 % | Parametrica Management Ltd | 320,276 | 224,876 | 31.12.2023 |
0.11 % | BlackRock Advisors (UK) Limited | 314,282 | 22,423 | 31.3.2024 |
0.11 % | Stifel, Nicolaus & Company, Incorporated | 307,754 | 77,600 | 31.12.2023 |
0.11 % | Nomura Asset Management Co., Ltd. | 305,301 | 9,002 | 30.11.2023 |
0.11 % | HRT Financial LP | 294,763 | 294,763 | 31.12.2023 |
0.10 % | Citadel Advisors LLC | 286,034 | -103,101 | 31.12.2023 |
0.10 % | Hudson Bay Capital Management LP | 275,000 | -155,200 | 31.12.2023 |
0.10 % | Wells Fargo Advisors | 274,287 | 70,093 | 31.12.2023 |
0.09 % | Manulife Investment Management (North America) Limited | 264,971 | 1,042 | 31.12.2023 |
0.09 % | Driehaus Capital Management, LLC | 257,959 | 257,959 | 29.2.2024 |
0.09 % | TD Asset Management Inc. | 257,460 | -78,618 | 31.12.2023 |
0.09 % | Credit Suisse International | 256,936 | -26,620 | 31.12.2023 |
0.09 % | AllianceBernstein L.P. | 252,890 | -90,300 | 31.12.2023 |
0.09 % | CM Management, LLC | 250,000 | 50,000 | 31.12.2023 |